William Upham (August 5, 1792 - January 14, 1853) was a United States Senator from Vermont. Born in Leicester, Massachusetts, he moved with his father to Montpelier in 1802. He attended the district schools, the Montpelier Academy, and was privately tutored; he studied law and was admitted to the bar in 1811 and commenced practice in Montpelier in 1812. He was a member of the Vermont House of Representatives, 1827-1828 and was State's attorney for Washington County in 1829; he was again a member of the Vermont House of Representatives in 1830. In 1843 he was elected as a Whig to the U.S. Senate in 1843. He was reelected in 1849 and served from March 4, 1843 until his death in Washington, D.C. in 1853. While in the Senate, he was chairman of the Committee on Agriculture (Twenty-eighth Congress) and a member of the Committee on Pensions (Twenty-ninth Congress). Interment was in the Congressional Cemetery.
Preceded by: Samuel Crafts U.S. Senator (Class 3) from Vermont 1843-1853 Served alongside: Samuel S. Phelps, Solomon Foot Succeeded by: Samuel S. Phelps