Perrette studied sociology, psychology and criminal science in college. She graduated with honours and later went on to earn a Master's Degree in Criminal Science.

Perhaps somewhat related is the profession of her character Abby Sciuto on the TV series NCIS, as she is a forensic scientist. Abby is an interesting part of the gallery of personae, with her relatively eccentric style and personality. Perrette has also had roles in a range of films and some TV series, including several guest appearances in a large number of TV series.

Perrette supports many charity organizations, including animal rescue, the American Red Cross, civil rights, gay rights, etc.

Perrette is not only an actress; she is also a writer, singer, photographer and a poet. She was the lead singer in the Los Angeles based all female band Lo-Ball.