Morgan was born in Toronto, but because she and her family moved to Los Angeles, California soon afterwards, she gained dual-citizenship in the U.S. and Canada. As an infant and small child, Webb appeared in advertisements for Gerber baby food, Kenner Toys, and most famously, an ad for McDonald's, where she recited the ingredients of the Big Mac to a game of Pattycake. Ironically, Webb's parents refused to let her watch television as a child, so she made up for lost hours of television time by playing video games. She began with an Atari, primarily the game Combat, but as technology progressed, The Legend of Zelda and Phantasy Star became two of her favorite games.

Webb graduated from North Hollywood High School in 1996 with Highly Gifted Magnet honors. After graduating high school, she left home to attend UC Berkeley. While there, she earned a bachelor's degree in rhetoric and a minor in Italian.

Webb developed computer skills in her free time at Berkeley, and after graduating from college, worked for a dot-com company as a website administrator. After the company went under during the dot-com bubble burst of 2000, her friend Catherine Schwartz pulled her in at TechTV in 2001 and Morgan became employed as the associate producer and web researcher for The Screen Savers. Thanks to her extremely vast self-taught knowledge of computers and technology, she was quickly promoted to an on-screen member of the program where she presented daily in-depth segments dealing with Microsoft Windows and Linux operating systems, and on select occasions hosted The Screen Savers herself. Throughout 2002 and 2003, she also regularly co-hosted Call For Help with Chris Pirillo. In April 2003, Webb left The Screen Savers to co-host X-Play with Adam Sessler.

In April 2004, Webb, along with fellow TechTV personalities Sarah Lane, Laura Swisher, Catherine Schwartz and Melanie Kim, was included in the "TechTV's Sexiest Techie" poll sponsored by Playboy magazine. TechTV viewers could vote for their favorite girl via the Playboy website, and the winner of the poll would be offered a nude photo spread in a future issue of Playboy. Webb won the poll, and despite being "very flattered" by the photo shoot offer, she immediately refused, citing her own personal reasons, as well as her parents' objection to the idea.

Throughout 2004, Webb was featured in numerous issues of FHM and Maxim magazines.

She was spotlighted in the July 2004 issue of Maxim She had a five-page feature article in the November 2004 issue of FHM She was rated 73rd in FHM's one-hundred sexiest women in the world for 2005, and 62nd in 2006 She was rated 39th on FHM's 2004 list of the fifty most eligible women in the world In August 2005, Webb became a contributing game columnist for FHM, alongside her regular hosting duties on X-Play. Her monthly column is entitled "Tips From The Gaming Goddess"; readers are encouraged to email Morgan their video game-related inquiries, she answers one question each month.

Webb has appeared in the music video Strange New Element from the band Low Water. She makes her appearance near the end of the video alongside other fellow TechTV personalities, including Catherine Schwartz, Sarah Lane, Laura Swisher, Chi-Lan Lieu and Sumi Das. In addition to appearing in Low Water's music video, Morgan is also featured in the artwork of the band's album, Hard Words In A Speakeasy.

Webb is one of only six TechTV personalities, including Adam Sessler, Sarah Lane, Chi-Lan Lieu, Kevin Rose, and Brendan Moran, to survive the massive layoffs resulting from the May 2004 merger of G4 and TechTV. Lieu, Rose, Lane and Moran have since left.

Webb currently resides in her second hometown of Los Angeles.