Stratton played five years with the Chicago White Sox (1934-38), compiling a career 36-23 record with 196 strikeouts and a 3.71 ERA in 487.1 innings. His majors career ended prematurely when a hunting accident in 1938 forced doctors to amputate his right leg.

A 6-foot-5-inch right hander, Stratton made his debut with the White Sox on June 2, 1934. He became a starter in 1937, winning 15 games with a 2.40 ERA and five shutouts, and made the American League All-Star squad. The following season, he also won 15 and completed 17 of his 22 starts.

On November 27, 1938 Stratton was hunting rabbits, when he slipped and fell, accidentally discharging his shotgun. The pellets struck his right leg, which had to be amputated the following day. Equipped with a wooden leg, Stratton worked with the White Sox the next two years as a coach and batting practice pitcher. When World War II started, he tried to enlist but was rejected. Then, he organized a semipro baseball team at Greenville, Texas, and constantly practiced coordination on the field.

In 1946, Stratton stunned the baseball world when he pitched again in the minors. His return to baseball was rough sledding because the other teams persistently bunted balls out of his reach, but Stratton was finally able to make a successful comeback winning 18 games with the Class-C Sherman in the East Texas League.

His comeback attempt was the subject of the film The Stratton Story (Sam Wood, 1949), which starred James Stewart and June Allyson, with big-leaguers Gene Bearden, Bill Dickey and Jimmy Dykes in cameo appearances.

Monty Stratton died in Greenville, Texas at age of 70.