Eduardo Villacis (born August 29, 1979 in Caracas, Venezuela), is a Major League Baseball right-handed starting pitcher who plays for the Chicago White Sox. Previously, he played with the Kansas City Royals (2004). Villacis debuted on May 1, 2004. Called up by the Royals from Double-A Wichita, he made one start against the Yankees, allowing five runs and six hits through 3.1 innings. Two days later, he was sent back to Wichita. On May 26, the White Sox claimed Villacis off waivers from Kansas City and optioned him to Double-A Birmingham.
Villacis has a 34-12 record with a 2.57 ERA in 158 career minor league games (52 starts). In one major league appearance, he has a 0-1 record with a 13.50 ERA. Chicago added him to its 40-man roster.
Villacis recently played for the Atlantic City Surf of the Independent League.