Seminick was born in Pierce, West Virginia. He was a member of the 1949 National League All-Star team and helped the 1950 "Whiz Kids" Phillies win their first penant since 1915. On June 2, 1949, he hit three home runs in a game with two of them in the same inning.

In 15 seasons, Seminick batted .243 with 164 home runs and 556 RBI in 1304 games. He enjoyed his best season in 1950, when he hit .288, 24, 68.

After retiring, Seminick worked for the Philadelphia organization for the rest of his life. First, as a coach with the Phillies (1957-58), then managed 11 Phillies' minor-league teams (1959-66, 1970-73), and returned as a coach for the Phillies (1967-69). After that, he scouted and served as a roving minor-league instructor for the Phillies (1974 to mid-1980s). Notably that ninety of his players he managed or coached eventually played in the major leagues, including Mike Schmidt, Ferguson Jenkins, Greg Luzinski and Bob Boone. Seminick helped to convert Boone from a third baseman to one of the best defensive catchers in baseball.

In the 1990s, Seminick served as a catching instructor for Philadelphia in spring training and in the Florida Instructional League.

Andy Seminick died in Melbourne, Florida, at 83 years of age. He was the last living everyday player from the Whiz Kids.

Feat On June 2, 1949, the Phillies hit five home runs during the same inning (the eighth) in a 12-3 victory over Cincinnati at Shibe Park, tying the major league mark set by the 1939 New York Giants. Seminick hit two home runs in the inning, while Del Ennis, Willie Jones and Schoolboy Rowe had one each. Jones added a triple as Granny Hamner's double jumped the extra bases total to 18, still a record. Seminick collected three home runs overall.

Other MLB debuts in 1943 Tommy Byrne Mickey Haefner Gil Hodges George Kell Andy Pafko Eddie Stanky Snuffy Stirnweiss Gene Woodling Al Zarilla